Ontology highlight
ABSTRACT:
SUBMITTER: Bai X
PROVIDER: S-EPMC10637943 | biostudies-literature | 2023 Nov
REPOSITORIES: biostudies-literature
Bai Xiaohui X Zhang Kun K Ou Chaopeng C Mu Yanyu Y Chi Dongmei D Zhang Jianxing J Huang Jingxiu J Li Xile X Zhang Yingjun Y Huang Wan W Ouyang Handong H
iScience 20231017 11
Dopamine D1 receptor-expressing medium spiny neurons (D1R-MSNs) and dopamine D2 receptor-expressing MSNs (D2R-MSNs) in nucleus accumbens (NAc) have been demonstrated to show different effects on reward and memory of abstinence. A-kinase anchoring protein 150 (AKAP150) expression in NAc is significantly upregulated and contributes to the morphine withdrawal behavior. However, the underlying mechanism of AKAP150 under opioid withdrawal remains unclear. In this study, AKAP150 expression in NAc is u ...[more]