Ontology highlight
ABSTRACT:
SUBMITTER: Yuan B
PROVIDER: S-EPMC10639057 | biostudies-literature | 2023 Nov
REPOSITORIES: biostudies-literature
Yuan Bo B Zhang Shuqian S Song Liting L Chen Jinlong J Cao Jixin J Qiu Jiayi J Qiu Zilong Z Chen Jingqi J Zhao Xing-Ming XM Cheng Tian-Lin TL
Nucleic acids research 20231101 20
Cytosine base editors (CBEs), which enable precise C-to-T substitutions, have been restricted by potential safety risks, including DNA off-target edits, RNA off-target edits and additional genotoxicity such as DNA damages induced by double-strand breaks (DSBs). Though DNA and RNA off-target edits have been ameliorated via various strategies, evaluation and minimization of DSB-associated DNA damage risks for most CBEs remain to be resolved. Here we demonstrate that YE1, an engineered CBE variant ...[more]