Ontology highlight
ABSTRACT:
SUBMITTER: Qiu C
PROVIDER: S-EPMC10641069 | biostudies-literature | 2023 Nov
REPOSITORIES: biostudies-literature
Qiu Chen C Zhang Zihan Z Wine Robert N RN Campbell Zachary T ZT Zhang Jun J Hall Traci M Tanaka TMT
Nature communications 20231113 1
PUF proteins are characterized by globular RNA-binding domains. They also interact with partner proteins that modulate their RNA-binding activities. Caenorhabditis elegans PUF protein fem-3 binding factor-2 (FBF-2) partners with intrinsically disordered Lateral Signaling Target-1 (LST-1) to regulate target mRNAs in germline stem cells. Here, we report that an intrinsically disordered region (IDR) at the C-terminus of FBF-2 autoinhibits its RNA-binding affinity by increasing the off rate for RNA ...[more]