Nitrogen isotopic composition as a gauge of tumor cell anabolism-to-catabolism ratio.
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ABSTRACT:
SUBMITTER: Straub M
PROVIDER: S-EPMC10643536 | biostudies-literature | 2023 Nov
REPOSITORIES: biostudies-literature
Publications
Nitrogen isotopic composition as a gauge of tumor cell anabolism-to-catabolism ratio.
Straub Marietta M Auderset Alexandra A de Leval Laurence L Piazzon Nathalie N Maison Damien D Vozenin Marie-Catherine MC Ollivier Jonathan J Petit Benoît B Sigman Daniel M DM Martínez-García Alfredo A
Scientific reports 20231113 1
Studies have suggested that cancerous tissue has a lower <sup>15</sup>N/<sup>14</sup>N ratio than benign tissue. However, human data have been inconclusive, possibly due to constraints on experimental design. Here, we used high-sensitivity nitrogen isotope methods to assess the <sup>15</sup>N/<sup>14</sup>N ratio of human breast, lung, and kidney cancer tissue at unprecedented spatial resolution. In lung, breast, and urothelial carcinoma, <sup>15</sup>N/<sup>14</sup>N was negatively correlated w ...[more]
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