Ontology highlight
ABSTRACT:
SUBMITTER: Liu Z
PROVIDER: S-EPMC10643901 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
Liu Zhe Z De Porto Alexander P N A APNA De Beer Regina R Roelofs Joris J T H JJTH De Boer Onno J OJ Florquin Sandrine S Van't Veer Cornelis C Hendriks Rudi W RW Van der Poll Tom T De Vos Alex F AF
Journal of innate immunity 20220510 1
Humans with dysfunctional Bruton's tyrosine kinase (Btk) are highly susceptible to bacterial infections. Compelling evidence indicates that Btk is essential for B cell-mediated immunity, whereas its role in myeloid cell-mediated immunity against infections is controversial. In this study, we determined the contribution of Btk in B cells and neutrophils to host defense against the extracellular bacterial pathogen Klebsiella pneumoniae, a common cause of pulmonary infections and sepsis. Btk-/- mic ...[more]