Ontology highlight
ABSTRACT:
SUBMITTER: Chen X
PROVIDER: S-EPMC10644524 | biostudies-literature | 2023 Nov
REPOSITORIES: biostudies-literature
Chen Xiu X Zhang Yu Y Zhang Pingping P Wei Mengzhu M Tian Tian T Guan Yanling Y Han Chenchen C Wei Wei W Ma Yang Y
Infectious agents and cancer 20231113 1
Metastasis has emerged as a major impediment to achieve successful therapeutic outcomes in hepatocellular carcinoma (HCC). Nonetheless, the intricate molecular mechanisms governing the progression of HCC remain elusive. Herein, we present evidence highlighting the influence exerted by insulin-like growth factor-binding protein 2 (IGFBP2) as a potent oncogene driving the malignant phenotype. Our investigation reveals a marked elevation of IGFBP2 expression in primary tumors, concomitant with the ...[more]