Ontology highlight
ABSTRACT:
SUBMITTER: Song Z
PROVIDER: S-EPMC10645843 | biostudies-literature | 2023 Nov
REPOSITORIES: biostudies-literature
Song Zili Z Zhou Shuang S Zhang Hongjiao H Keller Nancy P NP Oakley Berl R BR Liu Xiao X Yin Wen-Bing WB
Nature communications 20231114 1
Production of secondary metabolites is controlled by a complicated regulatory network in eukaryotic cells. Several layers of regulators are involved in this process, ranging from pathway-specific regulation, to epigenetic control, to global regulation. Here, we discover that interaction of an RNA-binding protein CsdA with a regulator RsdA coordinates fungal secondary metabolism. Employing a genetic deletion approach and transcriptome analysis as well as metabolomics analysis, we reveal that CsdA ...[more]