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GeneChip analyses of global transcriptional responses of murine macrophages to the lethal toxin of Bacillus anthracis.

ABSTRACT: We performed GeneChip analyses on RNA from Bacillus anthracis lethal toxin (LeTx)-treated RAW 264.7 murine macrophages to investigate global effects of anthrax toxin on host cell gene expression. Stringent analysis of data revealed that the expression of several mitogen-activated protein kinase kinase-regulatory genes was affected within 1.5 h post-exposure to LeTx. By 3.0 h, the expression of 103 genes was altered, including those involved in intracellular signaling, energy production, and protein metabolism.

SUBMITTER: Comer JE 

PROVIDER: S-EPMC1064962 | biostudies-literature | 2005 Mar

REPOSITORIES: biostudies-literature

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GeneChip analyses of global transcriptional responses of murine macrophages to the lethal toxin of Bacillus anthracis.

Comer Jason E JE   Galindo Cristi L CL   Chopra Ashok K AK   Peterson Johnny W JW  

Infection and immunity 20050301 3

We performed GeneChip analyses on RNA from Bacillus anthracis lethal toxin (LeTx)-treated RAW 264.7 murine macrophages to investigate global effects of anthrax toxin on host cell gene expression. Stringent analysis of data revealed that the expression of several mitogen-activated protein kinase kinase-regulatory genes was affected within 1.5 h post-exposure to LeTx. By 3.0 h, the expression of 103 genes was altered, including those involved in intracellular signaling, energy production, and prot  ...[more]

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