Science review: searching for gene candidates in acute lung injury.
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ABSTRACT:
SUBMITTER: Grigoryev DN
PROVIDER: S-EPMC1065043 | biostudies-literature | 2004 Dec
REPOSITORIES: biostudies-literature
Publications
Science review: searching for gene candidates in acute lung injury.
Grigoryev Dmitry N DN Finigan James H JH Hassoun Paul P Garcia Joe G N JG
Critical care (London, England) 20040630 6
Acute lung injury (ALI) is a complex and devastating illness, often occurring within the setting of sepsis, and carries an annual mortality rate of 30-50%. Although the genetic basis of ALI has not been fully established, an increasing body of evidence suggests that genetic predisposition contributes to disease susceptibility and severity. Significant difficulty exists, however, in defining the exact nature of these genetic factors, including large phenotypic variance, incomplete penetrance, com ...[more]
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