Ontology highlight
ABSTRACT:
SUBMITTER: Agata A
PROVIDER: S-EPMC10651735 | biostudies-literature | 2023
REPOSITORIES: biostudies-literature
Agata Ako A Ohtsuka Satoshi S Noji Ryota R Gotoh Hitoshi H Ono Katsuhiko K Nomura Tadashi T
Frontiers in cell and developmental biology 20231102
Changes in genomic structures underlie phenotypic diversification in organisms. Amino acid-changing mutations affect pleiotropic functions of proteins, although little is known about how mutated proteins are adapted in existing developmental programs. Here we investigate the biological effects of a variant of the GLI3 transcription factor (GLI3<sup>R1537C</sup>) carried in Neanderthals and Denisovans, which are extinct hominins close to modern humans. R1537C does not compromise protein stability ...[more]