Tapasin gene polymorphism in systemic onset juvenile rheumatoid arthritis: a family-based case-control study.

ABSTRACT: Juvenile rheumatoid arthritis (JRA) comprises a group of chronic systemic inflammatory disorders that primarily affect joints and can cause long-term disability. JRA is likely to be a complex genetic trait, or a series of such traits, with both genetic and environmental factors contributing to the risk for developing the disease and to its progression. The HLA region on the short arm of chromosome 6 has been intensively evaluated for genetic contributors to JRA, and multiple associations, and more recently linkage, has been detected. Other genes involved in innate and acquired immunity also map to near the HLA cluster on 6p, and it is possible that variation within these genes also confers risk for developing JRA. We examined the TPSN gene, which encodes tapasin, an endoplasmic reticulum c

SUBMITTER: Bukulmez H 

PROVIDER: S-EPMC1065319 | biostudies-literature | 2005

REPOSITORIES: biostudies-literature