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Distinct dynamics of the nucleolus in response to nutrient availability and during development in the rice blast fungus.

ABSTRACT:

Importance

The nucleolus is a dynamic subnuclear structure that is involved in many fundamental processes of the nucleus. In higher eukaryotic cells, the size and shape of nucleoli correlate with nucleolar activities. For fungi, knowledge of the nucleolus and its functions is primarily gleaned from budding yeast. Whether such correlation is conserved and how nucleolar functions are regulated in filamentous fungi including important human and crop pathogens are largely unknown. Our observations reveal that the dynamics of nucleolus in a model plant pathogenic fungus, Magnaporthe oryzae, is distinct from those of animal and yeast nucleoli under low nutrient availability and during pathogenic development. Our data not only provide new insight into the nucleoli in filamentous fungi but also highlight the need for investigating how nucleolar dynamics is regulated in comparison to other eukaryotes.

SUBMITTER: Cho E

PROVIDER: S-EPMC10653916 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature

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Distinct dynamics of the nucleolus in response to nutrient availability and during development in the rice blast fungus.

Cho Eunbyeol E Lee Song Hee SH Dean Ralph A RA Jeon Junhyun J

mBio 20230928 5

<h4>Importance</h4>The nucleolus is a dynamic subnuclear structure that is involved in many fundamental processes of the nucleus. In higher eukaryotic cells, the size and shape of nucleoli correlate with nucleolar activities. For fungi, knowledge of the nucleolus and its functions is primarily gleaned from budding yeast. Whether such correlation is conserved and how nucleolar functions are regulated in filamentous fungi including important human and crop pathogens are largely unknown. Our observ ...[more]

PMID: 37768072

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