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ABSTRACT:
SUBMITTER: Gong J
PROVIDER: S-EPMC10654394 | biostudies-literature | 2023 Nov
REPOSITORIES: biostudies-literature
Gong Junpyo J Yi Jeong Sang JS Cho Hang Su HS Shin Chang Hun CH Won Hyung-Jin HJ Cho Byung-Kwan BK Noh Minsoo M Yoon Yeo Joon YJ
Scientific data 20231116 1
Streptomyces clavuligerus NRRL 3585 is a native producer of clavulanic acid (CA), a clinically used β-lactamase inhibitor, and is widely used as an industrial strain for the production of antibiotics. Selective random mutagenesis has successfully generated the improved CA-producing S. clavuligerus mutant strains as well as the strain with the loss of CA biosynthesis. To understand the molecular mechanisms associated with the improved CA-production potential, genome-scale RNA-sequencing-based tra ...[more]