Ontology highlight
ABSTRACT:
SUBMITTER: Mei L
PROVIDER: S-EPMC10655893 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
Mei Ling L Yu Minzhi M Liu Yayuan Y Weh Eric E Pawar Mercy M Li Li L Besirli Cagri G CG Schwendeman Anna A AA
Nanomedicine : nanotechnology, biology, and medicine 20220524
Synthetic high-density lipoprotein (sHDL) and rapamycin (Rap) have both been shown to be potential treatments for age-related macular degeneration (AMD). The low aqueous solubility of Rap, however, limits its therapeutic utility. Here we used an Apolipoprotein A-I mimetic peptide and phospholipid-based sHDL for the intravitreal delivery of Rap. By incorporation of Rap in sHDL nanoparticles (sHDL-Rap), we achieve 125-fold increase in drug aqueous concentration. When applied in vitro to retinal pi ...[more]