Ontology highlight
ABSTRACT:
SUBMITTER: Wagenbauer KF
PROVIDER: S-EPMC10656288 | biostudies-literature | 2023 Aug
REPOSITORIES: biostudies-literature
Wagenbauer Klaus F KF Pham Nhi N Gottschlich Adrian A Kick Benjamin B Kozina Viktorija V Frank Christopher C Trninic Daniela D Stömmer Pierre P Grünmeier Ruth R Carlini Emanuele E Tsiverioti Christina Angeliki CA Kobold Sebastian S Funke Jonas J JJ Dietz Hendrik H
Nature nanotechnology 20230817 11
Multispecific antibodies have emerged as versatile therapeutic agents, and therefore, approaches to optimize and streamline their design and assembly are needed. Here we report on the modular and programmable assembly of IgG antibodies, F(ab) and scFv fragments on DNA origami nanocarriers. We screened 105 distinct quadruplet antibody variants in vitro for the ability to activate T cells in the presence of target cells. T-cell engagers were identified, which in vitro showed the specific and effic ...[more]