Ontology highlight
ABSTRACT:
SUBMITTER: Wang H
PROVIDER: S-EPMC10663540 | biostudies-literature | 2023 Nov
REPOSITORIES: biostudies-literature
Wang Haofeng H Yang Qi Q Liu Xiaoce X Xu Zili Z Shao Maolin M Li Dongxu D Duan Yinkai Y Tang Jielin J Yu Xianqiang X Zhang Yumin Y Hao Aihua A Wang Yajie Y Chen Jie J Zhu Chenghao C Guddat Luke L Chen Hongli H Zhang Leike L Chen Xinwen X Jiang Biao B Sun Lei L Rao Zihe Z Yang Haitao H
Nature communications 20231121 1
Since 2019, SARS-CoV-2 has evolved rapidly and gained resistance to multiple therapeutics targeting the virus. Development of host-directed antivirals offers broad-spectrum intervention against different variants of concern. Host proteases, TMPRSS2 and CTSL/CTSB cleave the SARS-CoV-2 spike to play a crucial role in the two alternative pathways of viral entry and are characterized as promising pharmacological targets. Here, we identify compounds that show potent inhibition of these proteases and ...[more]