Ontology highlight
ABSTRACT:
SUBMITTER: Lei M
PROVIDER: S-EPMC10667216 | biostudies-literature | 2023 Nov
REPOSITORIES: biostudies-literature
Lei Mingxing M Jiang Jingwei J Wang Mengyue M Wu Wang W Zhang Jinwei J Liu Wanqian W Zhou Wei W Lai Yung-Chih YC Jiang Ting-Xin TX Widelitz Randall B RB Harn Hans I-Chen HI Yang Li L Chuong Cheng-Ming CM
NPJ Regenerative medicine 20231123 1
Tissue patterning is critical for the development and regeneration of organs. To advance the use of engineered reconstituted skin organs, we study cardinal features important for tissue patterning and hair regeneration. We find they spontaneously form spheroid configurations, with polarized epidermal cells coupled with dermal cells through a newly formed basement membrane. Functionally, the spheroid becomes competent morphogenetic units (CMU) that promote regeneration of tissue patterns. The eme ...[more]