Long-term Ovariectomy Reduces Tolerance of Rats to Myocardial Ischemia-reperfusion Injury.

ABSTRACT:

Background

The harmful impact of ovariectomy on myocardial ischemia-reperfusion (M/IR) injury has been established in the short term.

Objectives

In this study, we aimed to investigate the long-term effects of ovariectomy on M/IR injury.

Methods

Two methods involving dorsolateral skin incisions were used to induce the ovariectomized (OVX) rat model. The rats were divided into 2 groups: Control and OVX (n = 6). At the end of the study, the hearts were isolated and subjected to global ischemia using the Langendorff apparatus. Cardiac function indices (CFIs) were recorded, including left ventricular end-diastolic pressure (LVEDP), peak rates of positive (+dp/dt) and negative (-dp/dt) changes in LV pressure, and LV-developed pressure (LVDP). At the end of the reperfusion p

SUBMITTER: Yousefzadeh N 

PROVIDER: S-EPMC10676666 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature