Ontology highlight
ABSTRACT:
SUBMITTER: Lear TB
PROVIDER: S-EPMC10679490 | biostudies-literature | 2023 Oct
REPOSITORIES: biostudies-literature
Lear Travis B TB Boudreau Áine N ÁN Lockwood Karina C KC Chu Elise E Camarco Daniel P DP Cao Qing Q Nguyen Matthew M Evankovich John W JW Finkel Toren T Liu Yuan Y Chen Bill B BB
The Journal of biological chemistry 20231027 12
The main protease of severe acute respiratory syndrome coronavirus 2, Mpro, is a key viral protein essential for viral infection and replication. Mpro has been the target of many pharmacological efforts; however, the host-specific regulation of Mpro protein remains unclear. Here, we report the ubiquitin-proteasome-dependent degradation of Mpro protein in human cells, facilitated by the human E3 ubiquitin ligase ZBTB25. We demonstrate that Mpro has a short half-life that is prolonged via proteaso ...[more]