Ontology highlight
ABSTRACT:
SUBMITTER: Kotb NM
PROVIDER: S-EPMC10680722 | biostudies-literature | 2023 Nov
REPOSITORIES: biostudies-literature
bioRxiv : the preprint server for biology 20231116
Genome organization can regulate gene expression and promote cell fate transitions. The differentiation of germline stem cells (GSCs) to oocytes in Drosophila involves changes in genome organization mediated by heterochromatin and the nuclear pore complex (NPC). Heterochromatin represses germ-cell genes during differentiation and NPCs anchor these silenced genes to the nuclear periphery, maintaining silencing to allow for oocyte development. Surprisingly, we find that genome organization also co ...[more]