Resting-state global brain activity affects early β-amyloid accumulation in default mode network.
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ABSTRACT:
SUBMITTER: Han F
PROVIDER: S-EPMC10682457 | biostudies-literature | 2023 Nov
REPOSITORIES: biostudies-literature
Publications
Resting-state global brain activity affects early β-amyloid accumulation in default mode network.
Han Feng F Liu Xufu X Mailman Richard B RB Huang Xuemei X Liu Xiao X
Nature communications 20231127 1
It remains unclear why β-amyloid (Aβ) plaque, a hallmark pathology of Alzheimer's disease (AD), first accumulates cortically in the default mode network (DMN), years before AD diagnosis. Resting-state low-frequency ( < 0.1 Hz) global brain activity recently was linked to AD, presumably due to its role in glymphatic clearance. Here we show that the preferential Aβ accumulation in the DMN at the early stage of Aβ pathology was associated with the preferential reduction of global brain activity in ...[more]
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