Dataset Information

Early environmental risk factors and coeliac disease in adolescents: a population-based cohort study in Denmark.

ABSTRACT:

Objectives

Our aim was to investigate the association between early environmental factors and the development of coeliac disease (CeD) in adolescents, recruited from a cohort nested in the Danish National Birth Cohort (DNBC).

Design

The study was designed as a prospective cohort study, nested in DNBC PARTICIPANTS: The Glutenfunen cohort comprises 1266 participants, nested in DNBC. All participants were screened for CeD, and in total, 28 cases of biopsy proven CeD were identified. Data about breastfeeding, timing of introduction to solid food in infancy, use of antibiotics, infections and symptoms were parentally reported prospectively at 6 months and 18 months, respectively. We estimated ORs and 95% CIs of CeD in adolescents using logistic regression analysis.

Results

Viral croup reported at 18 months of age was associated with CeD in adolescents with an OR of 3.2 (95% CI: 1.2 to 8.7). Furthermore, otitis media also reported at 18 months of age was linked with CeD with an OR of 3.2 (95% CI: 1.5 to 7.3). We were not able to find any statistical associations between CeD and breastfeeding, frequency of infections, parentally reported use of antibiotic and timing of solid foods.

Conclusion

In this study, we present an overview of the relationship between early environmental factors and occurrence of CeD in adolescents. Our findings, despite limitations due to a limited number of cases of CeD, suggest a role of viral infections in the pathogenesis of CeD.

SUBMITTER: Crawley C

PROVIDER: S-EPMC10685961 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature

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Publications

Early environmental risk factors and coeliac disease in adolescents: a population-based cohort study in Denmark.

Crawley Cæcilie C Sander Stine Dydensborg SD Nohr Ellen Aagaard EA Nybo Andersen Anne-Marie AM Husby Steffen S

BMJ open 20231127 11

<h4>Objectives</h4>Our aim was to investigate the association between early environmental factors and the development of coeliac disease (CeD) in adolescents, recruited from a cohort nested in the Danish National Birth Cohort (DNBC).<h4>Design</h4>The study was designed as a prospective cohort study, nested in DNBC PARTICIPANTS: The Glutenfunen cohort comprises 1266 participants, nested in DNBC. All participants were screened for CeD, and in total, 28 cases of biopsy proven CeD were identified. ...[more]

PMID: 38011980

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Dataset Information

Early environmental risk factors and coeliac disease in adolescents: a population-based cohort study in Denmark.

Objectives

Design

Results

Conclusion

Publications

Early environmental risk factors and coeliac disease in adolescents: a population-based cohort study in Denmark.

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