Rapid discovery of terpene tailoring enzymes for total biosynthesis.
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ABSTRACT:
SUBMITTER: Sun Y
PROVIDER: S-EPMC10686045 | biostudies-literature | 2023 Nov
REPOSITORIES: biostudies-literature
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Rapid discovery of terpene tailoring enzymes for total biosynthesis.
Sun Yunlong Y Gerke Jennifer J Becker Kevin K Kuhnert Eric E Verwaaijen Bart B Wibberg Daniel D Kalinowski Jörn J Stadler Marc M Cox Russell J RJ
Chemical science 20231108 46
Twenty oxygenated aristolochene congeners were rapidly synthesised by combining genes from four different fungal pathways in the fungal host organism <i>Aspergillus oryzae</i>. Compounds produced in a single step include the natural product hypoxylan A and an epimer of guignaderemophilane C. A new fungal aromatase was discovered that produces phenols by oxidative demethylation. ...[more]
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