SOX8 promotes tumor growth and metastasis through FZD6-dependent Wnt/β-catenin signaling in colorectal carcinoma.
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ABSTRACT:
SUBMITTER: Li C
PROVIDER: S-EPMC10686890 | biostudies-literature | 2023 Dec
REPOSITORIES: biostudies-literature
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SOX8 promotes tumor growth and metastasis through FZD6-dependent Wnt/β-catenin signaling in colorectal carcinoma.
Li Chen C Cheng Boran B Yang Xiaodong X Tong Gangling G Wang Fen F Li Mengqing M Wang Xiangyu X Wang Shubin S
Heliyon 20231121 12
SOX8 plays an important role in several physiological processes. Its expression is negatively associated with overall survival in patients with colorectal carcinoma (CRC), suggesting SOX8 is a potential prognostic factor for this disease. However, the role of SOX8 in CRC remains largely unknown. In this study, our data showed that <i>SOX8</i> expression was upregulated in CRC cell lines and tumor tissues. Stable knockdown of <i>SOX8</i> in CRC cell lines dramatically reduced cell proliferation, ...[more]
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