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Relationships among the O-antigen gene clusters of Salmonella enterica groups B, D1, D2, and D3.

ABSTRACT: The O antigen is an important cell wall antigen of gram-negative bacteria, and the genes responsible for its biosynthesis are located in a gene cluster. We have cloned and sequenced the DNA segment unique to the O-antigen gene cluster of Salmonella enterica group D3. This segment includes a novel O-antigen polymerase gene (wzyD3). The polymerase gives alpha(1-->6) linkages but has no detectable sequence similarity to that of group D2, which confers the same linkage. We find the remnant of a D3-like wzy gene in the O-antigen gene clusters of groups D1 and B and suggest that this is the original wzy gene of these O-antigen gene clusters.

SUBMITTER: Curd H

PROVIDER: S-EPMC106985 | biostudies-literature | 1998 Feb

REPOSITORIES: biostudies-literature

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Relationships among the O-antigen gene clusters of Salmonella enterica groups B, D1, D2, and D3.

Curd H H Liu D D Reeves P R PR

Journal of bacteriology 19980201 4

The O antigen is an important cell wall antigen of gram-negative bacteria, and the genes responsible for its biosynthesis are located in a gene cluster. We have cloned and sequenced the DNA segment unique to the O-antigen gene cluster of Salmonella enterica group D3. This segment includes a novel O-antigen polymerase gene (wzyD3). The polymerase gives alpha(1-->6) linkages but has no detectable sequence similarity to that of group D2, which confers the same linkage. We find the remnant of a D3-l ...[more]

PMID: 9473060

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2021-07-30 | PXD024305 | Pride

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