Ontology highlight
ABSTRACT:
SUBMITTER: Agrawal-Singh S
PROVIDER: S-EPMC10701772 | biostudies-literature | 2023 Dec
REPOSITORIES: biostudies-literature
Agrawal-Singh Shuchi S Bagri Jaana J Sakakini Nathalie N Huntly Brian J P BJP
Molecular oncology 20231102 12
Leukaemia stem cells (LSCs) are the critical seed for the growth of haematological malignancies, driving the clonal expansion that enables disease initiation, relapse and often resistance. Specifically, they display inherent phenotypic and epigenetic plasticity resulting in complex heterogenic diseases. In this review, we discuss the key principles of deregulation of epigenetic processes that shape this disease evolution. We consider measures to define and quantify clonal heterogeneity, combinin ...[more]