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Infection of wild-caught wood mice (Apodemus sylvaticus) and yellow-necked mice (A. flavicollis) with tick-borne encephalitis virus.

ABSTRACT: The distribution of tick-borne encephalitis virus (TBEV) is expanding to Western European countries, including the Netherlands, but the contribution of different rodent species to the transmission of TBEV is poorly understood. We investigated whether two species of wild rodents native to the Netherlands, the wood mouse Apodemus sylvaticus and the yellow-necked mouse Apodemus flavicollis, differ in their relative susceptibility to experimental infection with TBEV. Wild-caught individuals were inoculated subcutaneously with the classical European subtype of TBEV (Neudoerfl) or with TBEV-NL, a genetically divergent TBEV strain from the Netherlands. Mice were euthanised and necropsied between 3 and 21 days post-inoculation. None of the mice showed clinical signs or died during the experimental period. Nevertheless, TBEV RNA was detected up to 21 days in the blood of both mouse species and TBEV was also isolated from the brain of some mice. Moreover, no differences in infection rates between virus strains and mouse species were found in blood, spleen, or liver samples. Our results suggest that the wood mouse and the yellow-necked mouse may equally contribute to the transmission cycle of TBEV in the Netherlands. Future experimental infection studies that include feeding ticks will help elucidate the relative importance of viraemic transmission in the epidemiology of TBEV.

SUBMITTER: Bakker JW

PROVIDER: S-EPMC10703896 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature

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Infection of wild-caught wood mice (Apodemus sylvaticus) and yellow-necked mice (A. flavicollis) with tick-borne encephalitis virus.

Bakker Julian W JW Pascoe Emily L EL van de Water Sandra S van Keulen Lucien L de Vries Ankje A Woudstra Lianne C LC Esser Helen J HJ Pijlman Gorben P GP de Boer Willem F WF Sprong Hein H Kortekaas Jeroen J Wichgers Schreur Paul J PJ Koenraadt Constantianus J M CJM

Scientific reports 20231207 1

The distribution of tick-borne encephalitis virus (TBEV) is expanding to Western European countries, including the Netherlands, but the contribution of different rodent species to the transmission of TBEV is poorly understood. We investigated whether two species of wild rodents native to the Netherlands, the wood mouse Apodemus sylvaticus and the yellow-necked mouse Apodemus flavicollis, differ in their relative susceptibility to experimental infection with TBEV. Wild-caught individuals were ino ...[more]

PMID: 38062065

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Project description:For the last two decades, behavioral physiologists aimed to explain a plausible covariation between energetics and personality, predicted by the "pace-of-life syndrome" (POLS) hypothesis. However, the results of these attempts are mixed with no definitive answer as to which of the two most acknowledged models "performance" or "allocation" predicts covariation between consistent among-individual variation in metabolism and repeatable behavior (animal personality). The general conclusion is that the association between personality and energetics is rather context-dependent. Life-history, behavior, and physiology as well as its plausible covariation can be considered a part of sexual dimorphism. However, up to now, only a few studies demonstrated a sex-specific correlation between metabolism and personality. Therefore, we tested the relationships between physiological and personality traits in a single population of yellow-necked mice Apodemus flavicollis in the context of a plausible between-sexes difference in this covariation. We hypothesized that the performance model will explain proactive behavior in males and the allocation model will apply to females. Behavioral traits were determined using the latency of risk-taking and the open field tests, whereas the basal metabolic rates (BMR) was measured using indirect calorimetry. We have found a positive correlation between body mass-adjusted BMR and repeatable proactive behavior in male mice, which can support the performance model. However, the females were rather consistent mainly in avoidance of risk-taking that did not correlate with BMR, suggesting essential differences in personality between sexes. Most likely, the lack of convincing association between energetics and personality traits at the population level is caused by a different selection acting on the life histories of males and females. This may only result in weak support for the predictions of the POLS hypothesis when assuming that only a single model explaining the link between physiology and behavior operates in males and females. Thus, there is a need to consider the differences between sexes in behavioral studies to evaluate this hypothesis.

Dataset Information

Infection of wild-caught wood mice (Apodemus sylvaticus) and yellow-necked mice (A. flavicollis) with tick-borne encephalitis virus.

Publications

Infection of wild-caught wood mice (Apodemus sylvaticus) and yellow-necked mice (A. flavicollis) with tick-borne encephalitis virus.

Similar Datasets

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