Ontology highlight
ABSTRACT:
SUBMITTER: Zhu Q
PROVIDER: S-EPMC10710513 | biostudies-literature | 2023 Dec
REPOSITORIES: biostudies-literature
Zhu Qionghua Q Zhao Xin X Zhang Yuanhang Y Li Yanping Y Liu Shang S Han Jingxuan J Sun Zhiyuan Z Wang Chunqing C Deng Daqi D Wang Shanshan S Tang Yisen Y Huang Yaling Y Jiang Siyuan S Tian Chi C Chen Xi X Yuan Yue Y Li Zeyu Z Yang Tao T Lai Tingting T Liu Yiqun Y Yang Wenzhen W Zou Xuanxuan X Zhang Mingyuan M Cui Huanhuan H Liu Chuanyu C Jin Xin X Hu Yuhui Y Chen Ao A Xu Xun X Li Guipeng G Hou Yong Y Liu Longqi L Liu Shiping S Fang Liang L Chen Wei W Wu Liang L
Nature communications 20231209 1
Human cancer cell lines have long served as tools for cancer research and drug discovery, but the presence and the source of intra-cell-line heterogeneity remain elusive. Here, we perform single-cell RNA-sequencing and ATAC-sequencing on 42 and 39 human cell lines, respectively, to illustrate both transcriptomic and epigenetic heterogeneity within individual cell lines. Our data reveal that transcriptomic heterogeneity is frequently observed in cancer cell lines of different tissue origins, ofte ...[more]