Ontology highlight
ABSTRACT:
SUBMITTER: Goike J
PROVIDER: S-EPMC10713552 | biostudies-literature | 2023 Dec
REPOSITORIES: biostudies-literature
Goike Jule J Hsieh Ching-Lin CL Horton Andrew P AP Gardner Elizabeth C EC Zhou Ling L Bartzoka Foteini F Wang Nianshuang N Javanmardi Kamyab K Herbert Andrew A Abbassi Shawn S Xie Xuping X Xia Hongjie H Shi Pei-Yong PY Renberg Rebecca R Segall-Shapiro Thomas H TH Terrace Cynthia I CI Wu Wesley W Shroff Raghav R Byrom Michelle M Ellington Andrew D AD Marcotte Edward M EM Musser James M JM Kuchipudi Suresh V SV Kapur Vivek V Georgiou George G Weaver Scott C SC Dye John M JM Boutz Daniel R DR McLellan Jason S JS Gollihar Jimmy D JD
Communications biology 20231211 1
The ongoing evolution of SARS-CoV-2 into more easily transmissible and infectious variants has provided unprecedented insight into mutations enabling immune escape. Understanding how these mutations affect the dynamics of antibody-antigen interactions is crucial to the development of broadly protective antibodies and vaccines. Here we report the characterization of a potent neutralizing antibody (N3-1) identified from a COVID-19 patient during the first disease wave. Cryogenic electron microscop ...[more]