Ontology highlight
ABSTRACT:
SUBMITTER: Li J
PROVIDER: S-EPMC10716287 | biostudies-literature | 2023
REPOSITORIES: biostudies-literature
Li Junping J Li Changping C Huang Zhaoqi Z Huang Chunling C Liu Juanzhang J Wu Tao T Xu Shuwan S Mai Peibiao P Geng Dengfeng D Zhou Shuxian S Zhang Kun K Liu Zhaoyu Z
Frontiers in pharmacology 20231129
SGLT-2 inhibitors, such as empagliflozin, have been shown to reduce the occurrence of cardiovascular events and delay the progression of atherosclerosis. However, its role in atherosclerotic calcification remains unclear. In this research, ApoE<sup>-/-</sup> mice were fed with western diet and empagliflozin was added to the drinking water for 24 weeks. Empagliflozin treatment significantly alleviated arterial calcification assessed by alizarin red and von kossa staining in aortic roots and reduc ...[more]