Dataset Information

Osteoporosis and osteoarthritis: a bi-directional Mendelian randomization study.

ABSTRACT:

Objective

To investigate the causal relationship between low bone mineral density (BMD) and osteoarthritis (OA) using Mendelian randomization (MR) design.

Methods

Two-sample bi-directional MR analyses were performed using summary-level information on OA traits from UK Biobank and arcOGEN. Sensitivity analyses including MR-Egger, simple median, weighted median, MR pleiotropy residual sum, and outlier approaches were utilized in conjunction with inverse variance weighting (IVW). Gene ontology (GO) enrichment analyses and expression quantitative trait locus (eQTL) colocalization analyses were used to investigate the potential mechanism and shared genes between osteoporosis (OP) and OA.

Results

The IVW method revealed that genetically predicted low femoral neck BMD was significantly linked with hip (β = 0.105, 95% CI: 0.023-0.188) and knee OA (β = 0.117, 95% CI: 0.049-0.184), but not with other site-specific OA. Genetically predicted low lumber spine BMD was significantly associated with OA at any sites (β = 0.048, 95% CI: 0.011-0.085), knee OA (β = 0.101, 95% CI: 0.045-0.156), and hip OA (β = 0.150, 95% CI: 0.077-0.224). Only hip OA was significantly linked with genetically predicted reduced total bone BMD (β = 0.092, 95% CI: 0.010-0.174). In the reverse MR analyses, no evidence for a causal effect of OA on BMD was found. GO enrichment analysis and eQTL analysis illustrated that DDN and SMAD-3 were the most prominent co-located genes.

Conclusions

These findings suggested that OP may be causally linked to an increased risk of OA, indicating that measures to raise BMD may be effective in preventing OA. More research is required to determine the underlying processes via which OP causes OA.

SUBMITTER: Qu Y

PROVIDER: S-EPMC10717893 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature

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Publications

Osteoporosis and osteoarthritis: a bi-directional Mendelian randomization study.

Qu Yudun Y Chen Shibo S Han Mengling M Gu Ziqi Z Zhang Yujie Y Fan Tianxiang T Zeng Muhui M Ruan Guangfeng G Cao Peihua P Yang Qian Q Ding Changhai C Zhang Yan Y Zhu Zhaohua Z

Arthritis research & therapy 20231213 1

<h4>Objective</h4>To investigate the causal relationship between low bone mineral density (BMD) and osteoarthritis (OA) using Mendelian randomization (MR) design.<h4>Methods</h4>Two-sample bi-directional MR analyses were performed using summary-level information on OA traits from UK Biobank and arcOGEN. Sensitivity analyses including MR-Egger, simple median, weighted median, MR pleiotropy residual sum, and outlier approaches were utilized in conjunction with inverse variance weighting (IVW). Gen ...[more]

PMID: 38093316

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Dataset Information

Osteoporosis and osteoarthritis: a bi-directional Mendelian randomization study.

Objective

Methods

Results

Conclusions

Publications

Osteoporosis and osteoarthritis: a bi-directional Mendelian randomization study.

Similar Datasets

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