Ontology highlight
ABSTRACT:
SUBMITTER: Babaeijandaghi F
PROVIDER: S-EPMC10719395 | biostudies-literature | 2023 Dec
REPOSITORIES: biostudies-literature
Babaeijandaghi Farshad F Kajabadi Nasim N Long Reece R Tung Lin Wei LW Cheung Chun Wai CW Ritso Morten M Chang Chih-Kai CK Cheng Ryan R Huang Tiffany T Groppa Elena E Jiang Jean X JX Rossi Fabio M V FMV
Nature communications 20231213 1
Adult tissue-resident macrophages (RMs) are either maintained by blood monocytes or through self-renewal. While the presence of a nurturing niche is likely crucial to support the survival and function of self-renewing RMs, evidence regarding its nature is limited. Here, we identify fibro-adipogenic progenitors (FAPs) as the main source of colony-stimulating factor 1 (CSF1) in resting skeletal muscle. Using parabiosis in combination with FAP-deficient transgenic mice (Pdgfrα<sup>CreERT2</sup> × D ...[more]