Unknown

Dataset Information

0

The development of cancers research based on mitochondrial heat shock protein 90.

ABSTRACT: Mitochondrial heat shock protein 90 (mtHsp90), including Tumor necrosis factor receptor-associated protein 1 (TRAP1) and Hsp90 translocated from cytoplasm, modulating cellular metabolism and signaling pathways by altering the conformation, activity, and stability of numerous client proteins, and is highly expressed in tumors. mtHsp90 inhibition results in the destabilization and eventual degradation of its client proteins, leading to interference with various tumor-related pathways and efficient control of cancer cell development. Among these compounds, gamitrinib, a specific mtHsp90 inhibitor, has demonstrated its safety and efficacy in several preclinical investigations and is currently undergoing evaluation in clinical trials. This review aims to provide a comprehensive overview of the present knowledge pertaining to mtHsp90, encompassing its structure and function. Moreover, our main emphasis is on the development of mtHsp90 inhibitors for various cancer therapies, to present a thorough overview of the recent pre-clinical and clinical advancements in this field.

SUBMITTER: Xiang Y 

PROVIDER: S-EPMC10720920 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

The development of cancers research based on mitochondrial heat shock protein 90.

Xiang Yuchu Y   Liu Xudong X   Sun Qi Q   Liao Kuo K   Liu Xiaohan X   Zhao Zihui Z   Feng Lishuang L   Liu Yan Y   Wang Bo B  

Frontiers in oncology 20231130

Mitochondrial heat shock protein 90 (mtHsp90), including Tumor necrosis factor receptor-associated protein 1 (TRAP1) and Hsp90 translocated from cytoplasm, modulating cellular metabolism and signaling pathways by altering the conformation, activity, and stability of numerous client proteins, and is highly expressed in tumors. mtHsp90 inhibition results in the destabilization and eventual degradation of its client proteins, leading to interference with various tumor-related pathways and efficient  ...[more]

Similar Datasets

Unknown Discovery and development of heat shock protein 90 inhibitors.
| S-EPMC2760286 | biostudies-literature
Unknown Advances in the clinical development of heat shock protein 90 (Hsp90) inhibitors in cancers.
| S-EPMC3288123 | biostudies-other
Unknown Crowding Activates Heat Shock Protein 90.
| S-EPMC4813586 | biostudies-literature
Unknown Heat shock protein 90 is required for sexual and asexual development, virulence, and heat shock response in Fusarium graminearum.
| S-EPMC4910114 | biostudies-literature
Unknown Antimyeloma activity of heat shock protein-90 inhibition.
| S-EPMC1895907 | biostudies-literature
Unknown Heat Shock Protein 90 regulates encystation in Entamoeba.
| S-EPMC4602144 | biostudies-literature
Unknown Heat Shock Protein 90 (Hsp90)-Inhibitor-Luminespib-Loaded-Protein-Based Nanoformulation for Cancer Therapy.
| S-EPMC7465148 | biostudies-literature
Unknown Molecular cloning, phylogenetic analysis and heat shock response of Babesia gibsoni heat shock protein 90.
| S-EPMC5053942 | biostudies-literature
Unknown Heat shock protein 90 inhibitors repurposed against Entamoeba histolytica.
| S-EPMC4429810 | biostudies-literature
Unknown A secreted Heat shock protein 90 of Trichomonas vaginalis.
| S-EPMC5973626 | biostudies-literature