Ontology highlight
ABSTRACT:
SUBMITTER: Guo X
PROVIDER: S-EPMC10721635 | biostudies-literature | 2023 Dec
REPOSITORIES: biostudies-literature
Guo Xiaojia X Blanc Valerie V Davidson Nicholas O NO Velazquez Heino H Chen Tian-Min TM Moledina Dennis G DG Moeckel Gilbert W GW Safirstein Robert L RL Desir Gary V GV
Scientific reports 20231214 1
Cisplatin (CP) induces acute kidney injury (AKI) whereby proximal tubules undergo regulated necrosis. Repair is almost complete after a single dose. We now demonstrate a role for Apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 (Apobec-1) that is prominently expressed at the interface between acute and chronic kidney injury (CKD), in the recovery from AKI. Apobec-1 knockout (KO) mice exhibited greater mortality than in wild type (WT) and more severe AKI in both CP- and unilateral is ...[more]