Ontology highlight
ABSTRACT:
SUBMITTER: Fetsko AR
PROVIDER: S-EPMC10723338 | biostudies-literature | 2024 Feb
REPOSITORIES: biostudies-literature
Fetsko Audrey R AR Sebo Dylan J DJ Budzynski Lilyana B LB Scharbarth Alli A Taylor Michael R MR
bioRxiv : the preprint server for biology 20240207
During neuroinflammation, the proinflammatory cytokine Interleukin-1β (IL-1β) impacts blood-brain barrier (BBB) function by disrupting brain endothelial tight junctions, promoting vascular permeability, and increasing transmigration of immune cells. Here, we examined the effects of Il-1β on the <i>in vivo</i> development of the BBB. We generated a doxycycline-inducible transgenic zebrafish model that drives secretion of Il-1β in the CNS. To validate the utility of our model, we showed Il-1β dose ...[more]