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Electrochemical gold redox catalysis for selective oxidative arylation.

ABSTRACT: The combination of ArB(OH)₂ transmetallation with cationic gold(I) [LAu]⁺ and electrochemical anodic oxidation (EAO) approach was successfully developed for the preparation of Au^III-Ar intermediate for the first time. This in-situ generated aryl gold intermediate gave rapid and controllable transmetallation with ArB(OH)₂ or alkyne followed by reductive elimination to generate either di-aryl coupling or sp²-sp Sonogashira-type coupling products under mild conditions with no need of external oxidants, which significantly extended the versatility of electrochemical approach in promoting gold redox catalysis.

SUBMITTER: Zhang S

PROVIDER: S-EPMC10723655 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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Electrochemical gold redox catalysis for selective oxidative arylation.

Zhang Shuyao S Ye Xiaohan X Wojtas Lukasz L Hao Wenyan W Shi Xiaodong X

Green synthesis and catalysis 20210131 1

The combination of ArB(OH)2 transmetallation with cationic gold(I) [LAu]+ and electrochemical anodic oxidation (EAO) approach was successfully developed for the preparation of AuIII-Ar intermediate for the first time. This in-situ generated aryl gold intermediate gave rapid and controllable transmetallation with ArB(OH)2 or alkyne followed by reductive elimination to generate either di-aryl coupling or sp2-sp Sonogashira-type coupling ...[more]

PMID: 38106911

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