Ontology highlight
ABSTRACT:
SUBMITTER: Madsen JJ
PROVIDER: S-EPMC10724690 | biostudies-literature | 2023 Nov
REPOSITORIES: biostudies-literature
Madsen Jesper J JJ Petersen Jacob E JE Christensen Dan P DP Hansen Jakob B JB Schwartz Thue W TW Frimurer Thomas M TM Olsen Ole H OH
The Journal of biological chemistry 20231107 12
The tachykinin receptors neurokinin 1 (NK1R) and neurokinin 2 (NK2R) are G protein-coupled receptors that bind preferentially to the natural peptide ligands substance P and neurokinin A, respectively, and have been targets for drug development. Despite sharing a common C-terminal sequence of Phe-X-Gly-Leu-Met-NH2 that helps direct biological function, the peptide ligands exhibit some degree of cross-reactivity toward each other's non-natural receptor. Here, we investigate the detailed structure- ...[more]