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Tutorial on model selection and validation of model input into precision dosing software for model-informed precision dosing.


ABSTRACT: There has been rising interest in using model-informed precision dosing to provide personalized medicine to patients at the bedside. This methodology utilizes population pharmacokinetic models, measured drug concentrations from individual patients, pharmacodynamic biomarkers, and Bayesian estimation to estimate pharmacokinetic parameters and predict concentration-time profiles in individual patients. Using these individualized parameter estimates and simulated drug exposure, dosing recommendations can be generated to maximize target attainment to improve beneficial effect and minimize toxicity. However, the accuracy of the output from this evaluation is highly dependent on the population pharmacokinetic model selected. This tutorial provides a comprehensive approach to evaluating, selecting, and validating a model for input and implementation into a model-informed precision dosing program. A step-by-step outline to validate successful implementation into a precision dosing tool is described using the clinical software platforms Edsim++ and MwPharm++ as examples.

SUBMITTER: Taylor ZL 

PROVIDER: S-EPMC10725261 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature

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Tutorial on model selection and validation of model input into precision dosing software for model-informed precision dosing.

Taylor Zachary L ZL   Poweleit Ethan A EA   Paice Kelli K   Somers Katherine M KM   Pavia Kathryn K   Vinks Alexander A AA   Punt Nieko N   Mizuno Tomoyuki T   Girdwood Sonya Tang ST  

CPT: pharmacometrics & systems pharmacology 20231012 12


There has been rising interest in using model-informed precision dosing to provide personalized medicine to patients at the bedside. This methodology utilizes population pharmacokinetic models, measured drug concentrations from individual patients, pharmacodynamic biomarkers, and Bayesian estimation to estimate pharmacokinetic parameters and predict concentration-time profiles in individual patients. Using these individualized parameter estimates and simulated drug exposure, dosing recommendatio  ...[more]

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