Ontology highlight
ABSTRACT:
SUBMITTER: Taylor ZL
PROVIDER: S-EPMC10725261 | biostudies-literature | 2023 Sep
REPOSITORIES: biostudies-literature
Taylor Zachary L ZL Poweleit Ethan A EA Paice Kelli K Somers Katherine M KM Pavia Kathryn K Vinks Alexander A AA Punt Nieko N Mizuno Tomoyuki T Girdwood Sonya Tang ST
CPT: pharmacometrics & systems pharmacology 20231012 12
There has been rising interest in using model-informed precision dosing to provide personalized medicine to patients at the bedside. This methodology utilizes population pharmacokinetic models, measured drug concentrations from individual patients, pharmacodynamic biomarkers, and Bayesian estimation to estimate pharmacokinetic parameters and predict concentration-time profiles in individual patients. Using these individualized parameter estimates and simulated drug exposure, dosing recommendatio ...[more]