Ontology highlight
ABSTRACT:
SUBMITTER: Barnett KR
PROVIDER: S-EPMC10726428 | biostudies-literature | 2023 Dec
REPOSITORIES: biostudies-literature
Barnett Kelly R KR Mobley Robert J RJ Diedrich Jonathan D JD Bergeron Brennan P BP Bhattarai Kashi Raj KR Monovich Alexander C AC Narina Shilpa S Yang Wenjian W Crews Kristine R KR Manring Christopher S CS Jabbour Elias E Paietta Elisabeth E Litzow Mark R MR Kornblau Steven M SM Stock Wendy W Inaba Hiroto H Jeha Sima S Pui Ching-Hon CH Mullighan Charles G CG Relling Mary V MV Pruett-Miller Shondra M SM Ryan Russell J H RJH Yang Jun J JJ Evans William E WE Savic Daniel D
Cell genomics 20231120 12
B cell lineage acute lymphoblastic leukemia (B-ALL) is composed of diverse molecular subtypes, and while transcriptional and DNA methylation profiling has been extensively examined, the chromatin landscape is not well characterized for many subtypes. We therefore mapped chromatin accessibility using ATAC-seq in primary B-ALL cells from 156 patients spanning ten molecular subtypes and present this dataset as a resource. Differential chromatin accessibility and transcription factor (TF) footprint ...[more]