Ontology highlight
ABSTRACT:
SUBMITTER: Gui Y
PROVIDER: S-EPMC10728878 | biostudies-literature | 2023 Oct
REPOSITORIES: biostudies-literature
Gui Yijun Y Dahir Naima S NS Wu Yanan Y Downing Griffin G Sweeney Patrick P Cone Roger D RD
Cell reports 20231003 10
The melanocortin-3 receptor (MC3R) is a negative regulator of the central melanocortin circuitry via presynaptic expression on agouti-related protein (AgRP) nerve terminals, from where it regulates GABA release onto secondary MC4R-expressing neurons. However, MC3R knockout (KO) mice also exhibit defective behavioral and neuroendocrine responses to fasting. Here, we demonstrate that MC3R KO mice exhibit defective activation of AgRP neurons in response to fasting, cold exposure, or ghrelin while e ...[more]