S-EPMC10730342 - Atherosclerotic cardiovascular disease events among adults with high predicted risk without established risk factors. - OmicsDI

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Dataset Information

Atherosclerotic cardiovascular disease events among adults with high predicted risk without established risk factors.

ABSTRACT:

Objective

Age is the strongest contributor to 10-year predicted atherosclerotic cardiovascular disease (ASCVD) risk. Some older adults have a predicted ASCVD risk ≥7.5 %, without established risk factors. We sought to compare ASCVD incidence among adults with predicted ASCVD risk ≥7.5 %, with and without established ASCVD risk factors, to adults with predicted risk <7.5 %.

Methods

We analyzed data from REasons for Geographic and Racial Differences in Stroke study participants, 45-79 years old, without ASCVD or diabetes, not taking statins and with low-density lipoprotein cholesterol 70-189 mg/dL. Participants were categorized into 3 groups based on their 10-year predicted ASCVD risk and presence of established risk factors: <7.5 %, ≥7.5 % with established risk factors and ≥7.5 % without established risk factors. Established risk factors included smoking, systolic blood pressure ≥130 mmHg or antihypertensive medication use, total cholesterol ≥200 mg/dL, or high-density lipoprotein cholesterol <50 mg/dL for women (<40 mg/dL for men). Participants were followed for ASCVD events.

Results

Among 11,115 participants, 911 incident ASCVD events occurred over a median of 11.1 years. ASCVD incidence rates were 3.6, 12.8, and 9.8 per 1,000 person-years for participants with predicted risk <7.5 %, predicted risk ≥7.5 % with established risk factors and predicted risk ≥7.5 % without established risk factors, respectively. Compared to adults with predicted risk <7.5 %, hazard ratios for incident ASCVD in participants with risk ≥7.5 % with and without established risk factors were 3.58 (95 %CI 3.03 - 4.21) and 2.72 (95 %CI 1.91-3.88), respectively.

Conclusions

Adults with a 10-year predicted ASCVD risk ≥7.5 % but without established risk factors had a high ASCVD incidence.

SUBMITTER: Kong N

PROVIDER: S-EPMC10730342 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature

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Publications

Atherosclerotic cardiovascular disease events among adults with high predicted risk without established risk factors.

Kong Nathan N Sakhuja Swati S Colantonio Lisandro D LD Levitan Emily B EB Lloyd-Jones Donald M DM Cushman Mary M Muntner Paul P Polonsky Tamar S TS

American journal of preventive cardiology 20231122

<h4>Objective</h4>Age is the strongest contributor to 10-year predicted atherosclerotic cardiovascular disease (ASCVD) risk. Some older adults have a predicted ASCVD risk ≥7.5 %, without established risk factors. We sought to compare ASCVD incidence among adults with predicted ASCVD risk ≥7.5 %, with and without established ASCVD risk factors, to adults with predicted risk <7.5 %.<h4>Methods</h4>We analyzed data from REasons for Geographic and Racial Differences in Stroke study participants, 45- ...[more]

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