Ontology highlight
ABSTRACT:
SUBMITTER: Casanova-Sepulveda G
PROVIDER: S-EPMC10730565 | biostudies-literature | 2023 Dec
REPOSITORIES: biostudies-literature
Casanova-Sepúlveda Gabriela G Sexton Joel A JA Turk Benjamin E BE Boggon Titus J TJ
Nature communications 20231219 1
LIM domain kinases (LIMK) are important regulators of actin cytoskeletal remodeling. These protein kinases phosphorylate the actin depolymerizing factor cofilin to suppress filament severing, and are key nodes between Rho GTPase cascades and actin. The two mammalian LIMKs, LIMK1 and LIMK2, contain consecutive LIM domains and a PDZ domain upstream of the C-terminal kinase domain. The roles of the N-terminal regions are not fully understood, and the function of the PDZ domain remains elusive. Here ...[more]