Ontology highlight
ABSTRACT:
SUBMITTER: Jin Z
PROVIDER: S-EPMC10730695 | biostudies-literature | 2023 Dec
REPOSITORIES: biostudies-literature
Jin Zhangchu Z Shao Zhehua Z Yang Shiyi S Guo Anyi A Han Yinling Y Wu Yinfang Y Zhao Yun Y Wu Yanping Y Shen Jiaxin J Zhang Min M Zhan Xueqin X Diao Wenqi W Ying Songmin S Zhang Chao C Li Wen W Shen Huahao H Chen Zhihua Z Yan Fugui F
Cell death & disease 20231219 12
Increased levels of cytosolic DNA in lung tissues play an important role in acute lung injury. However, the detailed mechanisms involved remain elusive. Here, we found that cyclic GMP-AMP synthase (cGAS, a cytosolic DNA sensor) expression was increased in airway epithelium in response to increased cytosolic DNA. Conditional deletion of airway epithelial cGAS exacerbated acute lung injury in mice, cGAS knockdown augmented LPS-induced production of interleukin (IL)-6 and IL-8. Mechanically, deleti ...[more]