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Characterization of spatial lipidomic signatures in tick-bitten guinea pig skin as a model for host-vector-pathogen interaction profiling.

ABSTRACT:

Importance

Here, we demonstrate the adaptability of spatial "omics" methods to identify interphylum processes regulated at the vector-host interface of ticks during a mammalian blood meal. This approach enables a better understanding of complex bipartite or tripartite molecular interactions between hosts, arthropod vectors and transmitted pathogens, and contributes toward the development of spatially aware therapeutic target discovery and description.

SUBMITTER: Scott AJ

PROVIDER: S-EPMC10734475 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature

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Characterization of spatial lipidomic signatures in tick-bitten guinea pig skin as a model for host-vector-pathogen interaction profiling.

Scott Alison J AJ Smith Alexis A AA Heeren Ron M A RMA Pal Utpal U Ernst Robert K RK

mSystems 20231024 6

<h4>Importance</h4>Here, we demonstrate the adaptability of spatial "omics" methods to identify interphylum processes regulated at the vector-host interface of ticks during a mammalian blood meal. This approach enables a better understanding of complex bipartite or tripartite molecular interactions between hosts, arthropod vectors and transmitted pathogens, and contributes toward the development of spatially aware therapeutic target discovery and description. ...[more]

PMID: 37874165

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