Ontology highlight
ABSTRACT:
SUBMITTER: Varadarajan P
PROVIDER: S-EPMC1073664 | biostudies-literature | 2005 Apr
REPOSITORIES: biostudies-literature
Varadarajan Padmapriya P Mahalingam Sundarasamy S Liu Peiyun P Ng Sarah Boon Hsi SB Gandotra Sheetal S Dorairajoo Desmond Suresh Kumar DS Balasundaram David D
Molecular biology of the cell 20050119 4
We report that the fission yeast nucleoporin Nup124p is required for the nuclear import of both, retrotransposon Tf1-Gag as well as the retroviral HIV-1 Vpr. Failure to import Tf1-Gag into the nucleus in a nup124 null mutant resulted in complete loss of Tf1 transposition. Similarly, nuclear import of HIV-1 Vpr was impaired in nup124 null mutant strains and cells became resistant to Vpr's cell-killing activity. On the basis of protein domain similarity, the human nucleoporin Nup153 was identified ...[more]