Dataset Information

PdMo nanoflowers for endogenous/exogenous-stimulated nanocatalytic therapy.

ABSTRACT: The clinical application of reactive oxygen species (ROS)-mediated tumor treatment has been critically limited by inefficient ROS generation. Herein, we rationally synthesized and constructed the three-dimensional PdMo nanoflowers through a one-pot solvothermal reduction method for elaborately regulated peroxidase-like enzymatic activity and glutathione peroxidase-like enzymatic activity, to promote oxidation ROS evolvement and antioxidation glutathione depletion for achieving intensive ROS-mediated tumor therapy. The three-dimensional superstructure composed of two-dimensional nanosheet subunits can solve the issues by avoiding the appearance of tightly stacked crystalline nanostructures. Significantly, Mo is chosen as a second metal to alloy with Pd because of its more chemical valence and negative ionization energy than Pd for improved electron transfer efficiencies and enhanced enzyme-like activities. In addition, the photothermal effect generated by PdMo nanoflowers could also enhance its enzymatic activities. Thus, this work provides a promising paradigm for achieving highly ROS-mediated tumor therapeutic efficacy by regulating the multi-enzymatic activities of Pd-based nanoalloys.

SUBMITTER: Liang X

PROVIDER: S-EPMC10740153 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

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PdMo nanoflowers for endogenous/exogenous-stimulated nanocatalytic therapy.

Liang Xinqiang X Tang Yanping Y Kurboniyon Mekhrdod S MS Luo Danni D Tu Guiwan G Xia Pengle P Ning Shufang S Zhang Litu L Wang Chen C

Frontiers in pharmacology 20231207

The clinical application of reactive oxygen species (ROS)-mediated tumor treatment has been critically limited by inefficient ROS generation. Herein, we rationally synthesized and constructed the three-dimensional PdMo nanoflowers through a one-pot solvothermal reduction method for elaborately regulated peroxidase-like enzymatic activity and glutathione peroxidase-like enzymatic activity, to promote oxidation ROS evolvement and antioxidation glutathione depletion for achieving intensive ROS-medi ...[more]

PMID: 38143503

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PdMo nanoflowers for endogenous/exogenous-stimulated nanocatalytic therapy.

Publications

PdMo nanoflowers for endogenous/exogenous-stimulated nanocatalytic therapy.

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