Ontology highlight
ABSTRACT:
SUBMITTER: Fiorillo M
PROVIDER: S-EPMC10742319 | biostudies-literature | 2023 Dec
REPOSITORIES: biostudies-literature
Fiorillo Marco M Ricci Elena E Fava Mariarosa M Longobucco Camilla C Sotgia Federica F Rizza Pietro P Lanzino Marilena M Bonofiglio Daniela D Conforti Francesca Luisa FL Catalano Stefania S Barone Ines I Morelli Catia C Aquila Saveria S Lisanti Michael P MP Sisci Diego D
Cells 20231206 24
Tamoxifen-resistant breast cancer cells (TamR-BCCs) are characterized by an enhanced metabolic phenotype compared to tamoxifen-sensitive cells. FoxO3a is an important modulator of cell metabolism, and its deregulation has been involved in the acquisition of tamoxifen resistance. Therefore, tetracycline-inducible FoxO3a was overexpressed in TamR-BCCs (TamR/TetOn-AAA), which, together with their control cell line (TamR/TetOn-V), were subjected to seahorse metabolic assays and proteomic analysis. F ...[more]