Ontology highlight
ABSTRACT:
SUBMITTER: Galati S
PROVIDER: S-EPMC10743990 | biostudies-literature | 2023 Dec
REPOSITORIES: biostudies-literature
Galati Salvatore S Di Stefano Miriana M Bertini Simone S Granchi Carlotta C Giordano Antonio A Gado Francesca F Macchia Marco M Tuccinardi Tiziano T Poli Giulio G
International journal of molecular sciences 20231207 24
Glycogen synthase kinase-3 beta (GSK3β) is a serine/threonine kinase that plays key roles in glycogen metabolism, Wnt/β-catenin signaling cascade, synaptic modulation, and multiple autophagy-related signaling pathways. GSK3β is an attractive target for drug discovery since its aberrant activity is involved in the development of neurodegenerative diseases such as Alzheimer's and Parkinson's disease. In the present study, multiple machine learning models aimed at identifying novel GSK3β inhibitors ...[more]