Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC10747310 | biostudies-literature | 2023 Dec
REPOSITORIES: biostudies-literature
Zhang Yun Y Weh Katherine M KM Tripp Bridget A BA Clarke Jennifer L JL Howard Connor L CL Sunilkumar Shruthi S Howell Amy B AB Kresty Laura A LA
Pharmaceuticals (Basel, Switzerland) 20231207 12
We recently reported that cranberry proanthocyanidins (C-PACs) inhibit esophageal adenocarcinoma (EAC) by 83% through reversing reflux-induced bacterial, inflammatory and immune-implicated proteins and genes as well as reducing esophageal bile acids, which drive EAC progression. This study investigated whether C-PACs' mitigation of bile reflux-induced transporter dysregulation mechanistically contributes to EAC prevention. RNA was isolated from water-, C-PAC- and reflux-exposed rat esophagi with ...[more]