Ontology highlight
ABSTRACT:
SUBMITTER: Zannella C
PROVIDER: S-EPMC10748278 | biostudies-literature | 2023 Dec
REPOSITORIES: biostudies-literature
Zannella Carla C Chianese Annalisa A Monti Alessandra A Giugliano Rosa R Morone Maria Vittoria MV Secci Francesco F Sanna Giuseppina G Manzin Aldo A De Filippis Anna A Doti Nunzianna N Galdiero Massimiliano M
Pharmaceutics 20231217 12
Fusion is a key event for enveloped viruses, through which viral and cell membranes come into close contact. This event is mediated by viral fusion proteins, which are divided into three structural and functional classes. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein belongs to class I fusion proteins, characterized by a trimer of helical hairpins and an internal fusion peptide (FP), which is exposed once fusion occurs. Many efforts have been directed at finding ...[more]